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NFL Fantasy Football: 15 Must-Start Players

Here are 20 players that you have to start this week to have the most success in fantasy football!

QB: Joe Burrow, Bengals

PITTSBURGH, PENNSYLVANIA – SEPTEMBER 26: Joe Burrow #9 of the Cincinnati Bengals reacts after a first down during the third quarter in the game against the Pittsburgh Steelers at Heinz Field on September 26, 2021 in Pittsburgh, Pennsylvania. (Photo by Joe Sargent/Getty Images)

What happens when you combine a red-hot quarterback against the team that gives up the most explosive plays in the league? You lock him into your lineups and play him as he throws for 300 yards and 3 TDs.

QB: Patrick Mahomes, Chiefs

KANSAS CITY, MISSOURI – NOVEMBER 10: Patrick Mahomes #15 of the Kansas City Chiefs hands the football to Kareem Hunt #29 of the Kansas City Chiefs during the third quarter against the Denver Broncos at GEHA Field at Arrowhead Stadium on November 10, 2024 in Kansas City, Missouri. (Photo by David Eulitt/Getty Images)

Houston’s run defense is solid, but their pass defense has been a disaster. Mahomes is dealing with a bad ankle, but I still expect him to play well as the Chiefs seek a first-round BYE. Look for Mahomes to have 250 passing yards and 2 TDs.

QB: Baker Mayfield, Bucs

TAMPA, FLORIDA – DECEMBER 31: Baker Mayfield #6 of the Tampa Bay Buccaneers throws a pass during the fourth quarter against the New Orleans Saints at Raymond James Stadium on December 31, 2023 in Tampa, Florida. (Photo by Mike Ehrmann/Getty Images)

Baker has arguably played at an MVP level and gets the Cowboys, who have been reeling defensively. Vegas has the Bucs scoring four TDs; Baker should throw for three of those.

QB: Kyler Murray, Cardinals

Kyler Murray Arizona Cardinals
PHILADELPHIA, PENNSYLVANIA – DECEMBER 31: Kyler Murray #1 of the Arizona Cardinals reacts to a touchdown pass during the third quarter against the Philadelphia Eagles at Lincoln Financial Field on December 31, 2023 in Philadelphia, Pennsylvania. (Photo by Mitchell Leff/Getty Images)

Murray is maddeningly inconsistent, but when given time to throw, he is effective. Carolina struggles to put pressure on the quarterback, so Kyler should have time to find his receivers and put up 225 yards passing with 2 TDs.

QB: Aaron Rodgers, Jets

EAST RUTHERFORD, NEW JERSEY – OCTOBER 14: Aaron Rodgers #8 of the New York Jets throws a pass during the first quarter against the Buffalo Bills at MetLife Stadium on October 14, 2024 in East Rutherford, New Jersey. (Photo by Luke Hales/Getty Images)

Rodgers is just padding his stats as he decides on whether to return to the NFL in 2025. The more TDs he throws, the more he can ask for in his next contract. He should throw for 240 yards and another 2 TDs this week to get to 500 TDs in his career.

RB: Jahmyr Gibbs, Lions

DETROIT, MICHIGAN – DECEMBER 16: Jahmyr Gibbs #26 of the Detroit Lions runs the ball during the fourth quarter against the Denver Broncos at Ford Field on December 16, 2023 in Detroit, Michigan. (Photo by Rey Del Rio/Getty Images)

The Bears have allowed the second-most rushing yards to their opponents this season. David Montgomery will be out until the playoffs, and the Lions are working hard to get a BYE. Dan Campbell might not want to give Gibbs 25 touches, but I think he does. Gibbs goes for 150 yards and 2 TDs.

RB: James Cook, Bills

ORCHARD PARK, NEW YORK – NOVEMBER 19: James Cook #4 of the Buffalo Bills scores a touchdown in the second quarter against the New York Jets at Highmark Stadium on November 19, 2023 in Orchard Park, New York. (Photo by Bryan M. Bennett/Getty Images)

New England has been awful against the run all season. To wit, they have allowed the 4th most rushing TDs, the 4th most rushing yards, and the 7th highest yards per carry. I can not only see Cook scoring, but it wouldn’t shock me if Ray Davis scores, too.

RB: Bijan Robinson, Falcons

ATLANTA, GEORGIA – SEPTEMBER 17: Bijan Robinson #7 of the Atlanta Falcons rushes during the third quarter against the Green Bay Packers at Mercedes-Benz Stadium on September 17, 2023 in Atlanta, Georgia. (Photo by Todd Kirkland/Getty Images)

The Giants haven’t let up a ton of rushing TDs, but they have allowed the third most rushing yards to opposing running backs. I can’t imagine that the Falcons are going to want rookie Michael Penix throwing the ball a ton, so look for both Bijan and Tyler Allgeier to be heavily involved. Robinson should have 125 all-purpose yards and a TD.

RB: James Conner, Cardinals

NASHVILLE, TENNESSEE – SEPTEMBER 12: James Conner #6 celebrates with DeAndre Hopkins #10 of the Arizona Cardinals after a touchdown during the game against the Tennessee Titans at Nissan Stadium on September 12, 2021 in Nashville, Tennessee. The Cardinals defeated the Titans 38-13. (Photo by Wesley Hitt/Getty Images)

Carolina’s run defense has played better recently, but they still have allowed the most rushing yards, the most TDs, and the most yards per carry to opposing running backs this season. With Trey Benson injured and Demercado on the IR, Conner should have all the touches he can handle. Put him down for 130 yards and at least 1 TD.

RB: Jerome Ford, Browns

HOUSTON, TX – JANUARY 13: Jerome Ford #34 of the Cleveland Browns looks on from the field during an NFL wild-card playoff football game against the Houston Texans at NRG Stadium on January 13, 2024 in Houston, Texas. (Photo by Cooper Neill/Getty Images)

With Nick Chubb out for the season, Ford should get about 80% of the touches in the Browns backfield. What makes him an even better start is that this game has a real chance of exploding, as neither defense has been playing well. Ford should have 100 all-purpose yards and a TD.

WR: Ja’Marr Chase, Bengals

CINCINNATI, OHIO – NOVEMBER 28: Ja’Marr Chase #1 of the Cincinnati Bengals reacts in the second quarter against the Pittsburgh Steelers at Paul Brown Stadium on November 28, 2021 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images)

Chase is well on his way to scoring 20 TDs. This week, he plays Cleveland who loves to use man coverage (Chase’s favorite) and gives up the most explosive plays. If Tee Higgins misses the game with an injury, Chase could have 200+ receiving yards.

WR: Jaxon Smith-Njigba, Seahawks

SEATTLE, WASHINGTON – OCTOBER 22: Jaxon Smith-Njigba #11 of the Seattle Seahawks scores a touchdown in the first quarter of the game against the Arizona Cardinals at Lumen Field on October 22, 2023 in Seattle, Washington. (Photo by Jane Gershovich/Getty Images)

Who is the worst team in the league, DVOA wise, against slot WRs? Minnesota. Who does JSN play this week? Minnesota. Lock him in everywhere as he gets 100 receiving yards and a TD.

WR: Malik Nabers, Giants

Malik Nabers #9 of the New York Giants
EAST RUTHERFORD, NJ – AUGUST 08: Malik Nabers #9 of the New York Giants runs a route during an NFL football game against the Detroit Lions at MetLife Stadium on August 8, 2024 in East Rutherford, NJ. (Photo by Perry Knotts/Getty Images)

Atlanta has the second-worst DVOA to WR1 and has been getting peppered with targets regardless of the QB throwing him the ball. Look for Nabers to see another 12-14 targets with a great shot at 18-22 fantasy points.

WR: DeAndre Hopkins, Chiefs

KANSAS CITY, MISSOURI – NOVEMBER 10: DeAndre Hopkins #8 of the Kansas City Chiefs runs after the catch in the fourth quarter of a game against the Denver Broncos at GEHA Field at Arrowhead Stadium on November 10, 2024 in Kansas City, Missouri. (Photo by David Eulitt/Getty Images)

No one loves a revenge narrative more than I do, and this one is as good as it gets. Hopkins is playing for a playoff BYE against his old Texans team that has struggled against opposing receivers. Lock Hopkins in for 80 receiving yards and a TD.

WR: Tre Tucker, Raiders

LAS VEGAS, NEVADA – DECEMBER 16: Tre Tucker #11 of the Las Vegas Raiders runs up the field against the Atlanta Falcons in the first quarter of their game at Allegiant Stadium on December 16, 2024 in Las Vegas, Nevada. The Falcons defeated the Raiders 15-9. (Photo by Candice Ward/Getty Images)

Call it a hunch or call it Visionary, but Tucker is in a great spot to succeed. Aidan O’Connell is expected to return on Sunday, and the Raiders play the Jaguars, who play a ton of man coverage. O’Connell is not afraid to take a few chances deep to keep the defense honest. Tucker gets 85 receiving yards and finds the end zone.