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College Football Week 12 Game Predictions

COLUMBUS, OHIO – NOVEMBER 09: Wide receiver Jeremiah Smith #4 of the Ohio State Buckeyes seen in action during the game against the Purdue Boilermakers at Ohio Stadium on November 09, 2024 in Columbus, Ohio. (Photo by Jason Mowry/Getty Images)

#2 Ohio State vs. Northwestern: Ohio State is 8-1 on the season (5-1 in conference play). This game is not being played in Evanston. Instead, it will be held in the friendly confines of Wrigley Field. Freshman sensation Jeremiah Smith looks to add to his record-setting touchdown totals as the Buckeyes attempt to lock down a high playoff seed.

Score Prediction: Ohio State 45-13 

#5 Texas @ Arkansas

AUSTIN, TEXAS – NOVEMBER 09: Quinn Ewers #3 of the Texas Longhorns warms up before the game against the Florida Gators at Darrell K Royal-Texas Memorial Stadium on November 09, 2024 in Austin, Texas. (Photo by Tim Warner/Getty Images)

Texas (8-1) is coming off a huge thrashing of Florida, in which quarterback Quinn Ewers threw for five touchdowns in only three quarters of play. WR Isaiah Bond is healthy again and will be a difficult matchup for the Razorbacks secondary.

Score Prediction: Texas 40-14

#23 Clemson (pic) @ #18 Pittsburgh

CLEMSON, SOUTH CAROLINA – NOVEMBER 2: Cade Klubnik #2 of the Clemson Tigers runs the ball against the Louisville Cardinals at Memorial Stadium on November 2, 2024 in Clemson, South Carolina. (Photo by Isaiah Vazquez/Getty Images)

Pitt (7-2) has lost its last two games and now faces a tough Clemson team that beat Virginia Tech decisively last Saturday. This game is likely going to come down to which team can stop which running back, as Phil Mafah (Clemson) and Desmond Reid (Pitt) have been two of the top backs in CFB this season.

Score Prediction: Clemson 30-24

 Utah @ #20 Colorado

BOULDER, CO – OCTOBER 26: Head coach Deion Sanders of the Colorado Buffaloes yells toward the referee in the second half against the Cincinnati Bearcats at Folsom Field on October 26, 2024 in Boulder, Colorado. (Photo by Dustin Bradford/Getty Images)

Utah is coming off a controversial last-second loss at home to BYU. The Utah AD was fined 40K for his comments about the officiating. Now the Utes have to go on the road and play the always controversial Deion Sanders-led Colorado Buffaloes. Will Utah have an answer for Shadeur Sanders and the vaunted CU passing attack?

Score Prediction: Colorado 30-23

#6 Penn State @ Purdue

STATE COLLEGE, PA – NOVEMBER 09: Drew Allar #15 of the Penn State Nittany Lions attempts a pass against the Washington Huskies during the first half at Beaver Stadium on November 09, 2024 in State College, Pennsylvania. (Photo by Scott Taetsch/Getty Images)

Penn State totally dominated Washington in its last game and now gets the Boilermakers, who were just shellacked by Ohio State last week 45-0. This needs to be a statement game for the Nittany Lions, as they need to show that they have similar firepower to OSU.

Score Prediction: Penn State 42-6

Virginia @ #10 Notre Dame

SOUTH BEND, INDIANA – NOVEMBER 09: Riley Leonard #13 of the Notre Dame Fighting Irish throws a pass against the Florida State Seminoles during the first half at Notre Dame Stadium on November 09, 2024 in South Bend, Indiana. (Photo by Michael Reaves/Getty Images)

Notre Dame will operate with an implied team total of 36.5 points versus a Virginia defense that is being shredded through the air, allowing 282.0 passing yards per game (127th in the country). Notre Dame quarterback Riley Leonard is better known for his running prowess, but this might be a week where he throws for multiple scores.

Score Prediction: 45-10

Boston College @ #13 SMU

DALLAS, TEXAS – NOVEMBER 02: Kevin Jennings #7 of the Southern Methodist Mustangs warms up before a game against the Pittsburgh Panthers at Gerald J. Ford Stadium on November 02, 2024 in Dallas, Texas. (Photo by Sam Hodde/Getty Images)

Kevin Jennings and the Mustangs will be operating with an implied team total of 34 points versus a Boston College defense that is allowing 264.4 passing yards per game (115th in the country). Jennings has been really solid since taking over as the QB1 for the Mustangs, and BC just lost their QB1 to an injury.

Score Prediction: SMU 35-28

#15 LSU @ Florida

JACKSONVILLE, FLORIDA – NOVEMBER 02: Head coach Billy Napier of the Florida Gators reacts to a call during the first half of a game against the Georgia Bulldogs at EverBank Stadium on November 02, 2024 in Jacksonville, Florida. (Photo by James Gilbert/Getty Images)

Florida Head Coach Billy Napier got the dreaded public statement of support from the UF athletic director, but it still might not be enough to save his job. The only chance that the Gators have of keeping this game remotely competitive is if freshman quarterback D.J. Lagway plays. Lagway has missed the last two games, but there is hope that he will return on Saturday.

Score Prediction: LSU 31-23

#1 Oregon @ Wisconsin

EUGENE, OREGON – NOVEMBER 9: Quarterback Dillon Gabriel #8 of the Oregon Ducks prepares for a play during the first half of the game against the Maryland Terrapins at Autzen Stadium on November 9, 2024 in Eugene, Oregon. (Photo by Ali Gradischer/Getty Images)

The #1 Oregon Ducks (10-0, 7-0 Big Ten) go on the road to face Wisconsin on Saturday from Camp Randall Stadium in Madison. Wisconsin is coming off a BYE week after getting drubbed against Iowa. It’s hard to see anything slowing Ducks QB Dillon Gabriel in this matchup.

Score Prediction: Oregon 50-17

#7 Tennessee @ #3 Georgia

OXFORD, MISSISSIPPI – NOVEMBER 09: Carson Beck #15 of the Georgia Bulldogs warms up before the game against the Mississippi Rebels at Vaught-Hemingway Stadium on November 09, 2024 in Oxford, Mississippi. (Photo by Justin Ford/Getty Images)

The competitiveness in this game hangs on the injury situation of Vols QB quarterback Nico Iamaleava, who suffered a blow to the head in the 33-14 win over Mississippi State this past weekend. Tennessee head coach Josh Heupel says that Iamaleava is in great shape and expects him to play. Georgia has its own star quarterback, Carson Beck, and a strong desire to get back on the winning track after losing last week to Ole Miss.

Score Prediction: 23-17