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NFL: 5 Must Start QB In Fantasy Football Week 16

PITTSBURGH, PENNSYLVANIA – SEPTEMBER 26: Joe Burrow #9 of the Cincinnati Bengals reacts after a first down during the third quarter in the game against the Pittsburgh Steelers at Heinz Field on September 26, 2021 in Pittsburgh, Pennsylvania. (Photo by Joe Sargent/Getty Images)

QB: Joe Burrow, Bengals:

What happens when you combine a red-hot quarterback against the team that gives up the most explosive plays in the league? You lock him into your lineups and play him as he throws for 300 yards and 3 TDs.

QB: Patrick Mahomes, Chiefs

KANSAS CITY, MISSOURI – NOVEMBER 10: Patrick Mahomes #15 of the Kansas City Chiefs hands the football to Kareem Hunt #29 of the Kansas City Chiefs during the third quarter against the Denver Broncos at GEHA Field at Arrowhead Stadium on November 10, 2024 in Kansas City, Missouri. (Photo by David Eulitt/Getty Images)

Houston’s run defense is solid, but their pass defense has been a disaster. Mahomes is dealing with a bad ankle, but I still expect him to play well as the Chiefs seek a first-round BYE. Look for Mahomes to have 250 passing yards and 2 TDs.

QB: Baker Mayfield, Bucs

TAMPA, FLORIDA – DECEMBER 31: Baker Mayfield #6 of the Tampa Bay Buccaneers throws a pass during the fourth quarter against the New Orleans Saints at Raymond James Stadium on December 31, 2023 in Tampa, Florida. (Photo by Mike Ehrmann/Getty Images)

Baker has arguably played at an MVP level and gets the Cowboys, who have been reeling defensively. Vegas has the Bucs scoring four TDs; Baker should throw for three of those.

QB: Kyler Murray, Cardinals

Kyler Murray Arizona Cardinals
PHILADELPHIA, PENNSYLVANIA – DECEMBER 31: Kyler Murray #1 of the Arizona Cardinals reacts to a touchdown pass during the third quarter against the Philadelphia Eagles at Lincoln Financial Field on December 31, 2023 in Philadelphia, Pennsylvania. (Photo by Mitchell Leff/Getty Images)

Murray is maddeningly inconsistent, but when given time to throw, he is effective. Carolina struggles to put pressure on the quarterback, so Kyler should have time to find his receivers and put up 225 yards passing with 2 TDs.

QB: Aaron Rodgers, Jets

EAST RUTHERFORD, NEW JERSEY – OCTOBER 14: Aaron Rodgers #8 of the New York Jets throws a pass during the first quarter against the Buffalo Bills at MetLife Stadium on October 14, 2024 in East Rutherford, New Jersey. (Photo by Luke Hales/Getty Images)

Rodgers is just padding his stats as he decides on whether to return to the NFL in 2025. The more TDs he throws, the more he can ask for in his next contract. He should throw for 240 yards and another 2 TDs this week to get to 500 TDs in his career.