The Panthers have the worst DVOA against opposing running backs and Barkley is having an MVP type of season. A lot of people are commenting that they think that he won’t need to do that much in this game and that he might be benched in the fourth quarter, but if that happens, he likely has 150 rushing yards and two touchdowns on the stat sheet.
Alvin Kamara, Saints
No Taysom Hill changes the entire way the Saints feature Kamara. He won’t lose any short touchdowns, and he will get even more passes thrown to him out of the backfield. The Giants are reeling, and Kamara should be able to have an 18-25 point fantasy week.
Kyren Williams, Rams
The best way for the Rams to compete is to keep the time of possession and the Bills offense off the field. Additionally, the Bills Achilles heel has been their susceptibility to power running backs. If I know it, then for sure, you know that Sean McVay knows it too. Look for Williams to get at least 20 carries and have 100 yards rushing and a touchdown.
Tony Pollard, Titans
The Jaguars have the second-worst DVOA against opposing running backs, and Pollard has been a stalwart for the Titans this season. He feels like a lock for 100 all-purpose yards and a touchdown.
Isaac Guerendo, 49ers
Here we are in week 14, and Isaac Guerendo might be winning people fantasy leagues. Expect the 49ers to give him somewhere around 25 touches, specifically because the Bears have allowed the sixth most rushing yards to opposing running backs. I think Guerendo goes for at least 85 rushing yards and scores a touchdown.